GEO Mod6_06.qx
نویسنده
چکیده
منابع مشابه
Evaluation of the cardiotoxicity and resuscitation of rats of a newly developed mixture of a QX-314 analog and levobupivacaine
OBJECTIVE This study was designed to evaluate the cardiotoxicity of a QX-314 analog (QX-OH) and a mixture of QX-OH and levobupivacaine (LL-1) and to compare the ability to resuscitate rats after asystole induced by levobupivacaine (Levo-BUP), QX-314, QX-OH, and LL-1. METHODS First, we used the "up-and-down" method to determine median dose resulting in appearance of cardiotoxicity (CD50C) and ...
متن کاملThe Quaternary Lidocaine Derivative QX-314 Produces Long-Lasting Intravenous Regional Anesthesia in Rats
BACKGROUND The lidocaine derivative, QX-314, produces long-lasting regional anesthesia in various animal models. We designed this study to examine whether QX-314 could produce long-lasting intravenous regional anesthesia (IVRA) in a rat model. METHODS IVRA was performed on tail of rats. EC50 (median effective concentration) of QX-314 in IVRA was determined by up-and-down method. IVRA on tail ...
متن کاملComparison of the transport of QX-314 through TRPA1, TRPM8, and TRPV1 channels
BACKGROUND It has been demonstrated that N-ethyl-lidocaine (QX-314) can target the transient receptor protein vanilloid 1 (TRPV1) nociceptors when coadministered with capsaicin, resulting in a selective block of the nociceptors. Capsaicin is problematic in therapeutic use because it induces firing of nociceptors. The present study aimed to search for substitutes for capsaicin. We also examined ...
متن کاملPermeation and block of TRPV 1 channels by the cationic lidocaine derivative QX - 314 1 2 3 4
37 QX-314 (N-ethyl-lidocaine) is a cationic lidocaine derivative that blocks voltage38 dependent sodium channels when applied internally to axons or neuronal cell bodies. Co39 application of external QX-314 together with the TRPV1 agonist capsaicin produces 40 long-lasting sodium channel inhibition in TRPV1-expressing neurons, suggestive of QX41 314 entry into the neurons. We asked whether QX-3...
متن کاملFull-length Characterization of S1 Gene of Iranian QX Avian Infectious Bronchitis Virus Isolates, 2015
Background and Aims: Avian infectious bronchitis (IB) has prevalent in the most chicken farms during recent years, in spite of the IB vaccination program which has been widely performed in Iran. To better understand the molecular epidemiology of IBV in Iran, the full length sequences of S1 gene of Iranian QX IBVs were determined and phylogenetic analysis was done using some sequences of IBV. M...
متن کامل